Cancer Genes

Insert a gene identifier

Accepted identifiers:


Multiple query

Search for cancer genes within a genomic region Chr: Start: End:
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miRNA-Cancer Gene Interactions

Insert a target gene or miRNA identifier

Accepted identifiers:

  • Target Gene Symbol (e.g. PTEN)
  • Target Gene Entrez ID (e.g. 5728)
  • miRNA Identifier (e.g. hsa-mir-126)
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OncomiRs

Insert a miRNA identifier
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Description

NCG 4.0 reports information on:

  • duplicability
  • orthology
  • evolutionary appearance
  • interactions
  • function
  • expression

of a manually curated list of 2,000 protein-coding cancer genes and 64 OncomiRs.

Cancer genes are genes with a driver role in the onset of human cancer upon mutations of their sequence and/or amplifications of their genomic locus.

537 are known cancer genes from the Cancer Gene Census and from a list of genes that undergo cancer-specific amplifications. Their involvement in cancer is documented in the literature.

1463 are candidate cancer genes that derive from the manual curation of 77 whole genome or whole exome cancer-resequencing screenings. Their involvement in cancer is inferred with various statistical methods.

Cancer genes in NCG 4.0 are mutated in 23 cancer types:

  • Bladder
  • Breast
  • Cholangiocarcinoma
  • Colorectal
  • Endometrium
  • Gastric
  • Glioblastoma
  • Head and neck squamous cell carcinoma
  • Kidney
  • Leukemia
  • Liver
  • Lung
  • Lymphoma
  • Medulloblastoma
  • Melanoma
  • Myelodysplasia
  • Myeloma
  • Neuroblastoma
  • Oligodendroglioma
  • Ovarian
  • Pancreas
  • Prostate
  • Sarcoma

Please use our most recent publication for citing NCG: An et. al., Database, 2014